Open AccessImproved method for inducing chronic atrophic gastritis in mice
Author(s) -
Xian Fu Wei,
Xueping Feng,
Lu-Yao Wang,
Yan-Qiang Huang,
LanChang Liang,
Xiaoting Mo,
Hong-Yu Wei
Publication year - 2019
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v11.i12.1115
Subject(s) - intestinal metaplasia , atrophic gastritis , medicine , helicobacter pylori , cancer , h&e stain , intraepithelial neoplasia , gastroenterology , pathogenesis , stomach , gastric mucosa , precancerous condition , gastritis , pathology , metaplasia , staining , adenocarcinoma , prostate
Chronic atrophic gastritis (CAG) is a common disease of the digestive system with pathological characteristics of a decreasing number, or disappearance, of inherent glands of the gastric mucosa. CAG has been defined as a precancerous condition of gastric cancer. Intestinal metaplasia or intraepithelial neoplasia accompanying atrophied glands of the stomach is regarded as one of the most important precancerous lesions of gastric cancer. As a common malignant tumour, gastric cancer remains without a satisfactory therapy and its pathogenesis remains unclear, seriously threatening human life. Therefore, some scholars have proposed to prevent the incidence of gastric cancer by avoiding precancerous lesions. If CAG can be reversed, the incidence of gastric cancer can be substantially reduced. To reverse and prevent CAG and study its pathogenesis and therapy, it is necessary to develop an ideal, safe, stable, animal model.