Open AccessClinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
Author(s) -
Chunyang Zhang,
Jie Sun,
Xing Wang,
Cuifang Wang,
Xiandong Zeng
Publication year - 2019
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v11.i1.9
Subject(s) - colorectal cancer , immunohistochemistry , malignancy , medicine , clinical significance , cancer , cancer research , blot , downregulation and upregulation , carcinogenesis , lymphovascular invasion , real time polymerase chain reaction , pathology , biology , gene , metastasis , genetics
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract. The worldwide mortality rate of CRC is about one half of its morbidity. Ubiquitin is a key regulatory factor in the cell cycle and widely exists in eukaryotes. Human leukocyte antigen F-associated transcript 10 (FAT10), known as diubiquitin, is an 18 kDa protein with 29% and 36% homology with the N and C termini of ubiquitin. The function of FAT10 has not been fully elucidated, and some studies have shown that it plays an important role in various cell processes.