Open AccessPotential of casein kinase I in digestive cancer screening
Author(s) -
Cristina Modak
Publication year - 2009
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v1.i1.26
Subject(s) - medicine , kinase , cancer , casein kinase 1 , pathological , pancreatic cancer , colorectal cancer , carcinogenesis , disease , cancer research , casein kinase 2 , protein kinase a , bioinformatics , pathology , biochemistry , biology , cell cycle , cyclin dependent kinase 2
Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer's disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential therapeutic targets in treatment of digestive cancers. In this review, we summarize up to date what is known about this family of kinases and their involvement in carcinogenesis and other pathological conditions. Our emphasis is on their implications in digestive cancers and their potential for cancer screening and therapy.