Open AccessPrimary hepatic benign schwannoma
Author(s) -
Michihiro Hayashi,
Atsushi Takeshita,
Kazuhide Yamamoto,
Nobuhiko Tanigawa
Publication year - 2012
Publication title -
world journal of gastrointestinal surgery
Language(s) - English
Resource type - Journals
ISSN - 1948-9366
DOI - 10.4240/wjgs.v4.i3.73
Subject(s) - schwannoma , gist , medicine , neurofibromatosis , stromal tumor , differential diagnosis , cd34 , pathology , pathological , liver tumor , lesion , stromal cell , hepatocellular carcinoma , biology , stem cell , genetics
Schwannoma is predominantly a benign neoplasm of the Schwann cells in the neural sheath of the peripheral nerves. Occurrence of schwannoma in parenchymatous organs, such as liver, is extremely rare. A 64-year-old man without neurofibromatosis was observed to have a space-occupying lesion of 23mm diameter in the liver during follow-up examination for a previously resected gastrointestinal stromal tumor (GIST) in the small intestine. He underwent lateral segmentectomy of the liver under a provisional diagnosis of hepatic metastatic recurrence of the GIST. Histological examination confirmed the diagnosis of a benign schwannoma, confirmed by characteristic pathological findings and positive immunoreactions with the neurogenic marker S-100 protein, but negative for c-kit, or CD34. The tumor was the smallest among the reported cases. When the primary hepatic schwannoma is small in size, preoperative clinical diagnosis is difficult. Therefore, this disease should be listed as differential diagnosis for liver tumor with clinically benign characteristics.