Open AccessPredictive significance of cancer related-inflammatory markers in locally advanced rectal cancer
Author(s) -
Kitinat Timudom,
Thawatchai Akaraviputh,
Vitoon Chinswangwatanakul,
Ananya Pongpaibul,
Pornpim Korpraphong,
Janjira Petsuksiri,
Suthinee Ithimakin,
Atthaphorn Trakarnsanga
Publication year - 2020
Publication title -
world journal of gastrointestinal surgery
Language(s) - English
Resource type - Journals
ISSN - 1948-9366
DOI - 10.4240/wjgs.v12.i9.390
Subject(s) - medicine , colorectal cancer , pathological , tumor infiltrating lymphocytes , stage (stratigraphy) , total mesorectal excision , t stage , neoadjuvant therapy , chemoradiotherapy , gastroenterology , cancer , magnetic resonance imaging , predictive marker , oncology , radiology , breast cancer , immunotherapy , paleontology , biology
Locally advanced rectal cancer is treated using neoadjuvant chemoradiation (nCRT), followed by total mesorectal excision (TME). Tumor regression and pathological post-treatment stage are prognostic for oncological outcomes. There is a significant correlation between markers representing cancer-related inflammation, including high neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte (MLR) and unfavorable oncological outcomes. However, the predictive role of these markers on the effect of chemoradiation is unknown.