Open AccessRetrospective cohort study of statin therapy effect on resected colorectal liver metastases
Author(s) -
Edward Alabraba,
Hussein Ibrahim,
Adina Olaru,
Iain C. Cameron,
Dhanny Gomez
Publication year - 2020
Publication title -
world journal of gastrointestinal surgery
Language(s) - English
Resource type - Journals
ISSN - 1948-9366
DOI - 10.4240/wjgs.v12.i2.34
Subject(s) - medicine , colorectal cancer , retrospective cohort study , statin , cohort , oncology , surgery , cancer
Above and beyond their role in cardiovascular risk reduction, statins appear to have a chemopreventive role in some gastro-intestinal cancers. In the quest for new chemopreventive agents, some existing established drugs such as statins have shown potential for re-purposing as chemoprevention. Probing existing drugs, whose pharmacodynamics are familiar, for novel beneficial effects offers a more cost-effective and less time-consuming strategy than establishing brand new drugs whose pharmacodynamic profile is unfamiliar. Observational studies show statins decrease the risk of developing colorectal cancer but there are no published studies exploring the potential impact of statins on carcinogenesis in colorectal liver metastases (CRLM).