Open AccessExosomal noncoding RNAs in cholangiocarcinoma: Laboratory noise or hope?
Author(s) -
Konstantinos Laschos,
Dimitra Ioanna Lampropoulou,
Gerasimos Aravantinos,
Maria Piperis,
Dimitrios Filippou,
George Theodoropoulos,
Maria Gazouli
Publication year - 2020
Publication title -
world journal of gastrointestinal surgery
Language(s) - English
Resource type - Journals
ISSN - 1948-9366
DOI - 10.4240/wjgs.v12.i10.407
Subject(s) - long non coding rna , medicine , noise (video) , computational biology , surgery , biology , rna , genetics , computer science , artificial intelligence , gene , image (mathematics)
Currently, extracellular vesicles and particularly exosomes have gained a lot of research interest due to their unique roles in several biological processes. Noncoding RNAs (microRNAs, long noncoding RNAs and circular RNAs) represent a class of functional RNA with distinct regulatory roles in tumorigenesis and cancer progression. Cholangiocarcinoma is a rare but highly aggressive type of malignancy that is very challenging to diagnose, especially in early stages; surgical resection still represents the sole potentially curative treatment option. Hence, there is an urgent need for the discovery of novel diagnostic and prognostic biomarkers. Hereby, we provide a comprehensive review of the most recent discoveries that focus on exosomal noncoding RNAs in cholangio-carcinoma with the aim to identify new molecular players that could be used as biomarkers and therapeutic targets.