Open AccessPositive evidence for vitamin A role in prevention of type 1 diabetes
Author(s) -
Somaye Yosaee,
Maryam Akbari Fakhrabadi,
Farzad Shidfar
Publication year - 2016
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v7.i9.177
Subject(s) - type 1 diabetes , medicine , autoimmunity , immune system , diabetes mellitus , autoimmune disease , insulin , immunology , vitamin d and neurology , vitamin , micronutrient , endocrinology , disease , pathology
Type 1 diabetes mellitus (T1DM) as one of the most well-known autoimmune disease, results from the destruction of β-cells in pancreas by autoimmune process. T1DM is fatal without insulin treatment. The expansion of alternative treatment to insulin is a dream to be fulfilled. Currently autoimmunity is considered as main factor in development of T1DM. So manipulation of the immune system can be considered as alternative treatment to insulin. For the past decades, vitamin A has been implicated as an essential dietary micronutrient in regulator of immune function. Despite major advantage in the knowledge of vitamin A biology, patients who present T1DM are at risk for deficiency in vitamin A and carotenoids. Applying such evidences, vitamin A treatment may be the key approach in preventing T1DM.