Open AccessRole of bile acids in the regulation of the metabolic pathways
Author(s) -
Hiroki Taoka,
Yoko Yokoyama,
Kohkichi Morimoto,
Naho Kitamura,
Tatsuya Tanigaki,
Yoko Takashina,
Kazuo Tsubota,
Mitsuhiro Watanabe
Publication year - 2016
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v7.i13.260
Subject(s) - farnesoid x receptor , signal transduction , metabolic pathway , g protein coupled bile acid receptor , lipid metabolism , receptor , metabolism , cell signaling , microbiology and biotechnology , bile acid , nuclear receptor , medicine , biochemistry , biology , transcription factor , gene
Recent studies have revealed that bile acids (BAs) are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological functions. Some major signaling pathways involving the nuclear BAs receptor farnesoid X receptor and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of BAs. BAs regulate their own homeostasis via signaling pathways. BAs also affect diverse metabolic pathways including glucose metabolism, lipid metabolism and energy expenditure. This paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome.