Open AccessDiabetes mellitus and cellular replacement therapy: Expected clinical potential and perspectives
Author(s) -
Alexander E. Berezin
Publication year - 2014
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v5.i6.777
Subject(s) - medicine , regenerative medicine , stem cell , cell therapy , stem cell therapy , progenitor cell , reprogramming , disease , diabetes mellitus , transplantation , bone marrow , type 2 diabetes mellitus , bioinformatics , intensive care medicine , cell , immunology , endocrinology , microbiology and biotechnology , biology , genetics
Diabetes mellitus (DM) is the most prevailing disease with progressive incidence worldwide. Despite contemporary treatment type one DM and type two DM are frequently associated with long-term major microvascular and macrovascular complications. Currently restoration of failing β-cell function, regulation of metabolic processes with stem cell transplantation is discussed as complements to contemporary DM therapy regimens. The present review is considered paradigm of the regenerative care and the possibly effects of cell therapy in DM. Reprogramming stem cells, bone marrow-derived mononuclear cells; lineage-specified progenitor cells are considered for regenerative strategy in DM. Finally, perspective component of stem cell replacement in DM is discussed.