Open AccessNkx6.2 synergizes with Cdx-2 in stimulating proglucagon gene expression
Author(s) -
Pei-Xiang Wang,
Zhihui Yü,
Steven Wong,
Tianru Jin
Publication year - 2011
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v2.i5.66
Subject(s) - proglucagon , transactivation , pax4 , cell culture , microbiology and biotechnology , enteroendocrine cell , gene expression , transcription factor , pdx1 , biology , gene , homeobox , endocrinology , endocrine system , genetics , hormone , glucagon like peptide 1 , type 2 diabetes , diabetes mellitus
To investigate whether the transactivator of the proglucagon gene (Gcg), Cdx-2, synergizes with other transcription factors in stimulating Gcg expression and the trans-differentiation of Gcg-expressing cells.