Open AccessThree-dimensional-arterial spin labeling perfusion correlation with diabetes-associated cognitive dysfunction and vascular endothelial growth factor in type 2 diabetes mellitus rat
Author(s) -
Ju-Wei Shao,
Jinde Wang,
Qian He,
Ying Yang,
Yongchao Zou,
Wei Su,
Shutian Xiang,
Jianbo Li,
Jing Fang
Publication year - 2021
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v12.i4.499
Subject(s) - medicine , diabetes mellitus , endothelial dysfunction , cardiology , perfusion , type 2 diabetes mellitus , vascular endothelial growth factor , type 2 diabetes , endocrinology , vegf receptors
Type 2 diabetes mellitus (T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia. The mechanisms of diabetes-associated cognitive dysfunction (DACD) have not been fully elucidated to date. Some studies proved lower cerebral blood flow (CBF) in the hippocampus was associated with poor executive function and memory in T2DM. Increasing evidence showed that diabetes leads to abnormal vascular endothelial growth factor (VEGF) expression and CBF changes in humans and animal models. In this study, we hypothesized that DACD was correlated with CBF alteration as measured by three-dimensional (3D) arterial spin labeling (3D-ASL) and VEGF expression in the hippocampus.