Open AccessDo different bariatric surgical procedures influence plasma levels of matrix metalloproteinase-2, -7, and -9 among patients with type 2 diabetes mellitus?
Author(s) -
WenChi Wu,
Wei-Jei Lee,
Tzong-His Lee,
Shuchun Chen,
Chih-Yen Chen
Publication year - 2020
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v11.i6.252
Subject(s) - medicine , insulin resistance , type 2 diabetes mellitus , endocrinology , diabetes mellitus , body mass index , sleeve gastrectomy , adipose tissue , gastroenterology , type 2 diabetes , obesity , weight loss , surgery , gastric bypass
Bariatric surgery is an efficient strategy for body weight and type 2 diabetes mellitus (T2DM) management. Abnormal lipid deposition in visceral organs, especially the pancreas and liver, might cause beta-cell dysfunction and insulin resistance. Extracellular matrix (ECM) remodeling allows adipose expansion, and matrix metalloproteinases (MMPs) play essential roles in ECM construction. MMP-2 and MMP-9 are the substrates of MMP-7. Different studies have reported that MMP-2, -7, and -9 increase in patients with obesity and metabolic syndromes or T2DM and are considered biomarkers in obesity and hyperglycemia patients.