Open AccessMaternal low protein diet induces persistent expression changes in metabolic genes in male rats
Author(s) -
Allan de Oliveira Lira,
José Luiz Alves,
Mariana Pinheiro Fernandes,
Diogo Antônio Alves de Vasconcelos,
David Filipe de Santana,
João Henrique CostaSilva,
Béatrice Morio,
Carol Góis Leandro,
Luciano Pirola
Publication year - 2020
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v11.i5.182
Subject(s) - endocrinology , medicine , adipose tissue , pdk4 , biology , pyruvate kinase , gene expression , downregulation and upregulation , citrate synthase , leptin , lipid metabolism , adipogenesis , lipogenesis , glycolysis , gene , metabolism , biochemistry , enzyme , obesity
Perinatal exposure to a poor nutritional environment predisposes the progeny to the development of metabolic disease at the adult age, both in experimental models and humans. Numerous adaptive responses to maternal protein restriction have been reported in metabolic tissues. However, the expression of glucose/fatty acid metabolism-related genes in adipose tissue and liver needs to be described.