c-erbB-2 expression and prognosis of gastric cancer: a meta-analysis | Zendy

Zi-Xu Wang | Zendy; Bingyu Sun | Zendy

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c-erbB-2 expression and prognosis of gastric cancer: a meta-analysis

Author(s) -

Zi-Xu Wang,

Bingyu Sun

Publication year - 2015

Publication title -

genetics and molecular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.356

H-Index - 48

ISSN - 1676-5680

DOI - 10.4238/2015.march.13.5

Subject(s) - hazard ratio , confidence interval , meta analysis , cancer , medicine , oncology , proportional hazards model , gastroenterology

The prognostic role of c-erbB-2 in gastric cancer is controversial. We conducted a meta-analysis to evaluate the relationship between c-erbB-2 expression and the prognosis of gastric cancer. We evaluated 20 published studies assessing the relationship between c-erbB-2 and gastric cancer prognosis. The Revman 5.0 software was used to perform literature retrieval, article selection, data collection, and statistical analysis. We utilized a fixed-effect model to pool hazard ratios and 95% confidence intervals from the studies. A total of 20 eligible studies including 4468 gastric cancer patients were analyzed. We were unable to demonstrate the prognostic value of c-erbB-2 for gastric cancer (hazard ratio = 1.01, 95% confidence interval = 0.87-1.16, P = 0.93). The present study indicated that c-erbB-2 expression is not a prognostic factor for gastric cancer.

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