SET8 expression is associated with overall survival in gastric cancer | Zendy

Xiaolin Shi | Zendy; Zhiyong Guo | Zendy; X.L. Wang | Zendy; Xiong Liu | Zendy; Guangfeng Shi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

SET8 expression is associated with overall survival in gastric cancer

Author(s) -

Xiaolin Shi,

Zhiyong Guo,

X.L. Wang,

Xiong Liu,

Guangfeng Shi

Publication year - 2015

Publication title -

genetics and molecular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.356

H-Index - 48

ISSN - 1676-5680

DOI - 10.4238/2015.december.1.12

Subject(s) - cancer , confidence interval , medicine , oncology

SET8, a member of the SET domain-containing methyl-transferase, has been implicated in various biological processes. In this study, SET8 was immunostained in 100 samples of gastric cancer tissues and semi-quantified using the HSCORE method to determine the predictive value of SET8 expression levels for gastric cancer outcome. The relationship between SET8 expression and the 5-year survival rate of gastric cancer patients was assessed. High expression of SET8 was associated with a shorter survival time in gastric cancer patients, and the level of SET8 expression was found to be an independent predictor of gastric cancer outcome (relative risk = 1.939; 95% confidence interval = 1.025-3.668; P = 0.042). Analysis of SET8 levels may help in the identification of patient subgroups that are at high risk for poor disease outcomes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research