Open AccessGene expression of the p16INK4a-Rb and p19Arf-p53-p21Cip/Waf1 signaling pathways in the regulation of hematopoietic stem cell aging by ginsenoside Rg1
Author(s) -
Zhenggang Yue,
Rong Jiang,
Ping Wang,
Bing Yan,
Ying Xin,
Feng Li,
Yaping Wang
Publication year - 2014
Publication title -
genetics and molecular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.356
H-Index - 48
ISSN - 1676-5680
DOI - 10.4238/2014.december.4.3
Subject(s) - senescence , haematopoiesis , microbiology and biotechnology , signal transduction , stem cell , biology , gene , cancer research , genetics
The elucidation of the molecular mechanisms underlying the effects of traditional Chinese medicines in clinical practice is a key step toward their worldwide application, and this topic is currently a subject of intense research interest. Rg1, a component of ginsenoside, has recently been shown to perform several pharmacological functions; however, the underlying mechanisms of these effects remain unclear. In the present study, we investigated whether Rg1 has an anti-senescence effect on hematopoietic stem cells (HSCs) and the possible molecular mechanisms driving any effects. The results showed that Rg1 could effectively delay tert-butyl hydroperoxide (t-BHP)-induced senescence and inhibit gene expression in the p16(INK4a)-Rb and p19(Arf)-p53-p21(Cip/Waf1) signaling pathways in HSCs. Our study suggested that these two signaling pathways might be potential targets for elucidating the molecular mechanisms of the Rg1 anti-senescence effect.