Open AccessThe Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies
Author(s) -
Peter K. Panegyres,
Emily Atkins
Publication year - 2011
Publication title -
neuroscience and medicine
Language(s) - English
Resource type - Journals
eISSN - 2158-2947
pISSN - 2158-2912
DOI - 10.4236/nm.2011.24053
Subject(s) - amyloid precursor protein , amyloid precursor protein secretase , pharmacology , biochemistry , glutamate receptor , chemistry , receptor , biology , medicine , alzheimer's disease , disease
Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytokines, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials