Open AccessUsing Novel Statistical Techniques to Accurately Determine the Predictive Dose Range in a Study of Overall Survival after Definitive Radiotherapy for Stage III Non-Small Cell Lung Cancer in Association with Heart Dose
Author(s) -
Joshua R. Niska,
Jiuyun Hu,
Jing Li,
Michael Herman,
C.S. Thorpe,
Steven E. Schild,
M. Fatyga
Publication year - 2021
Publication title -
journal of cancer therapy
Language(s) - English
Resource type - Journals
eISSN - 2151-1942
pISSN - 2151-1934
DOI - 10.4236/jct.2021.129044
Subject(s) - medicine , lung cancer , radiation therapy , proportional hazards model , multivariate analysis , nuclear medicine , multivariate statistics , hazard ratio , stage (stratigraphy) , oncology , lung volumes , lung , confidence interval , statistics , mathematics , paleontology , biology
Recent studies of radiotherapy (RT) for stage III non-small-cell lung cancer (NSCLC) have associated high dose to the heart with cardiac toxicity and decreased overall survival (OS). We used advanced statistical techniques to account for correlations between dosimetric variables and more accurately determine the range of heart doses which are associated with reduced OS in patients receiving RT for stage III NSCLC.