Open Access<i>STYK1/NOK</i>—A Potential Radiotherapeutic Target and Biomarker for Gastric Cancer and Cervical Cancer
Author(s) -
Ling Gao,
Xiaohua Chen,
Zenghai Ma,
Fengsheng Li
Publication year - 2013
Publication title -
journal of cancer therapy
Language(s) - English
Resource type - Journals
eISSN - 2151-1942
pISSN - 2151-1934
DOI - 10.4236/jct.2013.42073
Subject(s) - radioresistance , cancer , cervical cancer , medicine , cancer research , biomarker , oncology , radiation therapy , biology , biochemistry
This article introduced the STYK1/NOK, including its origin, chemical composition and biological function, and the expression of STYK1/NOK in various cancer cell lines was reviewed. Furthermore, our recent study showed that STYK1/NOK protein was also over expressed in gastric cancer and cervical cancer specimens, and STYK1/NOK expression increased after tumor cells were irradiated with γ ray. These results indicated that STYK1/NOK might be involved in the occurrence and progress of gastric cancer and cervical cancer, and contribute to the radioresistance of tumor cells. Thus, STYK1/NOK might be a potential therapeutic target and diagnostic marker for gastric cancer and cervical cancer.