Open AccessThe clinical significance of CD97, NF-kB and COX-2 ingastric MALT lymphomas
Author(s) -
Shao-liang Han,
Jun Cheng,
Ximei Wu,
Zengrong Jia,
Pengfei Wang,
Zhanwei Wang
Publication year - 2011
Publication title -
journal of biomedical science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1937-688X
pISSN - 1937-6871
DOI - 10.4236/jbise.2011.47061
Subject(s) - lymphoma , submucosa , stage (stratigraphy) , helicobacter pylori , clinical significance , malt lymphoma , gastroenterology , pathology , gastric mucosa , medicine , stomach , biology , paleontology
Background and Objectives: Increased expression of the CD97, nuclear factor-kB (NF-kB) and cyclooxygenase-2 (COX-2) has been found to play an important role in development of many cancers, including gastric neoplasm. However, the expression and biological behavior of CD97, NF-kB and COX-2 in gastric MALT (mucosa-associated lymphoid tissue) lymphoma has not been well investigated. Methods: The expressions of CD97, COX-2 and NF-kB in 47 cases of gastric MALT lymphoma were detected immunohistochemically, and the relevance between their expressions and the biological behavior was analyzed retrospectively. Results: 1) The expressions of CD97, NF-kB and COX-2 were 87.2%, 36.2% and 48.9%, respectively; 2) The difference of CD97 expression between depth of invasion limited in mucosa and submucosa and beyond muscularis propria was significant (100.0% vs. 71.4%, P < 0.01). Moreover, the expression of nuclear CD97 between stage IIE, III, IV and stage I patients showed significant difference (96.4% vs. 73.7%, P < 0.05); 3) The expression of NF-kB was significantly correlated with tumor size, depth of invasion and stage; 4) The expression of COX-2 was significantly correlated with Helicobacter pylori infection, clinical stage, depth of invasion and tumor size (P < 0.05). Conclusions: Expressions of CD97, NF-κB and COX-2 were correlated with tumor invasion and metastasis in gastric MALT lymphoma