Open AccessTherapeutic Effects of Myriocin in Experimental Alcohol-Related Neurobehavioral Dysfunction and Frontal Lobe White Matter Biochemical Pathology
Author(s) -
Camilla Homans,
Emine Yalçın,
Ming Tong,
Gina Gallucci,
David Bautista,
Natalia Moriel,
Suzanne de la Monte
Publication year - 2022
Publication title -
journal of behavioral and brain science
Language(s) - English
Resource type - Journals
eISSN - 2160-5874
pISSN - 2160-5866
DOI - 10.4236/jbbs.2022.122003
Subject(s) - myelin , white matter , morris water navigation task , psychology , neuroscience , sphingomyelin , binge drinking , frontal lobe , sphingolipid , medicine , central nervous system , endocrinology , cognition , chemistry , alcohol , cholesterol , magnetic resonance imaging , biochemistry , alcohol consumption , radiology
Chronic excessive alcohol consumption causes white matter degeneration with myelin loss and impaired neuronal conductivity. Subsequent rarefaction of myelin accounts for the sustained deficits in cognition, learning, and memory. Correspondingly, chronic heavy or repeated binge alcohol exposures in humans and experimental models alter myelin lipid composition leading to build-up of ceramides which can be neurotoxic and broadly inhibitory to brain functions.