Open AccessThe Prevalence of Celiac Disease in Patients with Diabetes Mellitus—The Prevalence of Celiac Disease
Author(s) -
Deniz Gökalp,
Şenay Arıkan,
Mustafa Yakut,
Yekta Tüzün,
Alparslan Tuzcu,
Mithat Bahcecı,
İrfan Soykan
Publication year - 2011
Publication title -
international journal of clinical medicine
Language(s) - English
Resource type - Journals
eISSN - 2158-2882
pISSN - 2158-284X
DOI - 10.4236/ijcm.2011.23033
Subject(s) - medicine , gastroenterology , autoantibody , type 1 diabetes , diabetes mellitus , antibody , disease , population , immunology , endocrinology , environmental health
AIM: To determine the prevalence of celiac disease related autoantibodies in patients with type 1 and 2 diabetes mellitus (DM), and to compare these results with the general population. METHODS: In total, 137 consecutive patients with type 1 DM, 172 with type 2 DM and 113 age-sex matched control subjects were included into the study. Antigliadin-autoantibodies (AGA) IgG and IgA, and endomysial-antibodies(EMA) IgG and IgA antibodies were determined. Patients who were positive for one or more were offered a gastroduodenoscopic examination. RESULTS: AGA IgG positivity was detected in 38.7% (53/137) patients with type 1 DM in 26.2% (45/172) patients with type 2 DM and in 16.8% (19/113) control subjects (significant differences). AGA IgA positivity was detected in 24.8% (34/137) patients with type 1 DM, in 9.3% (16/172) patients with type 2 DM and in 3.5% (4/113) control subjects (significant differences). EMA IgG positivity was detected in 10.2% (14/137) patients with type 1 DM in 0.6% (1/176) patients with type 2 DM and 0.9% (1/113) control subjects (significant differences). EMA IgA positivity was detected in 11.7% (16/137) patients with type 1 DM in 0.6% (1/172) patients with type 2 DM and in none of control subjects. EMA IgA positivity was sig- nificantly higher in patients with type 1 DM as compared with patients with type 2 DM and controls. CONCLUSION: High prevalence of celiac disease at the diagnosis of type 1 DM is observed. Serological markers are useful for identifying celiac disease patients with type 1 DM