Open AccessATP binding cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia
Author(s) -
Stuart S. Winter,
Jerec Ricci,
Luo Lu,
Debbie M. Lovato,
Hadya M. Khawaja,
Tasha Serna-Gallegos,
Natalie DeBassige,
Richard S. Larson
Publication year - 2013
Publication title -
health
Language(s) - English
Resource type - Journals
eISSN - 1949-5005
pISSN - 1949-4998
DOI - 10.4236/health.2013.55a005
Subject(s) - abcc1 , vincristine , atp binding cassette transporter , multiple drug resistance , drug resistance , jurkat cells , biology , efflux , lymphoblast , multidrug resistance associated proteins , cancer research , pharmacology , immunology , cell culture , transporter , genetics , t cell , gene , chemotherapy , immune system , cyclophosphamide
In acute lymphoblastic leukemia (ALL), multidrug resistance is often mediated by ATPase Binding Cassette (ABC) proteins, which principally involve ABCB1 (multidrug resistance 1, MDR1 ) and ABCC1 (multidrug resistance protein 1, MRP1 ). However, direct comparisons between the differential effects of ABCB1 and ABCC1 have been difficult, since identical cell lines with differential expression of these transporters have not been developed.