Open AccessGliomatosis Cerebri: A Report of Three Cases with Literature Review
Author(s) -
Ali Hendi
Publication year - 2015
Publication title -
journal of king abdulaziz university. medical sciences
Language(s) - English
Resource type - Journals
ISSN - 1319-1004
DOI - 10.4197/med.22-4.5
Subject(s) - medicine , pathological , radiological weapon , epilepsy , personality changes , disease , radiology , presentation (obstetrics) , brain disease , stereotactic biopsy , biopsy , pediatrics , pathology , psychiatry
Gliomatosis cerebri is a rare glioma of poor prognosis due to its diff use infiltration of the central nervous system involving three or more lobes of the brain. It has non-specifi c symptoms such as epilepsy, cognitivedisorders, headache and change in personality. Three cases of gliomatosis cerebri are reported. Extensive literature review was done. This review includes defi nition, type, clinical presentation, diagnosis [radiological and pathological], deferential diagnosis, treatment, and prognosis. In conclusion gliomatosis cerebri was initially a postmortem diagnosis. Following the advancement of the MRI, it became a radiological diagnosis that induces diff use involvement of at least three contiguous lobes of the brain with relative preservationof its general anatomical confi guration. It is manifested clinically as a very aggressive disease with poor prognosis. Imaging plays an important role in initial diagnosis, biopsy planning and follow up.