Open AccessInflammasome gene expression alterations in Staphylococcus aureus biofilm-associated chronic rhinosinusitis
Author(s) -
Camille Jardeleza,
Dijana Miljkovic,
Leonie Baker,
Sam Boase,
Neil Tan,
Simon Koblar,
Peter D. Zalewski,
Maureen Rischmueller,
Susan Lester,
Amanda Drilling,
Dione Jones,
Lorwai Tan,
P J Wormald,
Sarah Vreugde
Publication year - 2013
Publication title -
rhinology (amsterdam. online)/rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.275
H-Index - 57
eISSN - 1996-8604
pISSN - 0300-0729
DOI - 10.4193/rhino13.045
Subject(s) - inflammasome , aim2 , medicine , staphylococcus aureus , biofilm , microbiology and biotechnology , chronic rhinosinusitis , immunology , nasal polyps , gene , inflammation , biology , bacteria , genetics
The role of inflammasomes in chronic inflammation has been the subject of intense research in recent years. Chronic rhinosinusitis (CRS), a persistent inflammatory disease, continues to be investigated hoping that a clearer pathophysiologic description will guide discovery of future treatment modalities. This study investigates the role of inflammasome complexes in CRS patients with Staphylococcus aureus biofilm infection, a key culprit associated with disease severity and recalcitrance.