Inflammasome gene expression alterations in Staphylococcus aureus biofilm-associated chronic rhinosinusitis | Zendy

Camille Jardeleza | Zendy; Dijana Miljkovic | Zendy; Leonie Baker | Zendy; Samuel Boase | Zendy; Neil Tan | Zendy; Simon A. Koblar | Zendy; Peter D. Zalewski | Zendy; Maureen Rischmueller | Zendy; Susan Lester | Zendy; Amanda Drilling | Zendy; Dione Jones | Zendy; L.W. Tan | Zendy; P.J. Wormald | Zendy; Sarah Vreugde | Zendy

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Inflammasome gene expression alterations in Staphylococcus aureus biofilm-associated chronic rhinosinusitis

Author(s) -

Camille Jardeleza,

Dijana Miljkovic,

Leonie Baker,

Samuel Boase,

Neil Tan,

Simon A. Koblar,

Peter D. Zalewski,

Maureen Rischmueller,

Susan Lester,

Amanda Drilling,

Dione Jones,

L.W. Tan,

P.J. Wormald,

Sarah Vreugde

Publication year - 2013

Publication title -

rhinology journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.275

H-Index - 57

eISSN - 1996-8604

pISSN - 0300-0729

DOI - 10.4193/rhino13.045

Subject(s) - inflammasome , aim2 , medicine , staphylococcus aureus , biofilm , microbiology and biotechnology , chronic rhinosinusitis , immunology , nasal polyps , gene , inflammation , biology , bacteria , genetics

The role of inflammasomes in chronic inflammation has been the subject of intense research in recent years. Chronic rhinosinusitis (CRS), a persistent inflammatory disease, continues to be investigated hoping that a clearer pathophysiologic description will guide discovery of future treatment modalities. This study investigates the role of inflammasome complexes in CRS patients with Staphylococcus aureus biofilm infection, a key culprit associated with disease severity and recalcitrance.

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