Open AccessClinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients - can chronic lung infections be postponed?
Author(s) -
Kasper Aanæs,
Helle Krogh Johansen,
Marianne Skov,
Frederik Buchvald,
Thomas Hjuler,
T. Pressler,
Niels Høiby,
Kim G. Nielsen,
Christian von Buchwald
Publication year - 2013
Publication title -
rhinology (amsterdam. online)/rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.275
H-Index - 57
eISSN - 1996-8604
pISSN - 0300-0729
DOI - 10.4193/rhino12.207
Subject(s) - medicine , cystic fibrosis , antibiotics , prospective cohort study , surgery , chronic rhinosinusitis , endoscopic sinus surgery , lung , sinus (botany) , paranasal sinuses , botany , microbiology and biotechnology , biology , genus
Background: The paranasal sinuses can be a bacterial reservoir for pulmonary infections in patients with cystic fibrosis (CF) METHODOLOGY: In this prospective, non-randomised, uncontrolled, intervention cohort study, the clinical effect of sinus surgery followed by two weeks` intravenous antibiotics, 6 months` antibiotic nasal irrigations was assessed in 106 CF patients. Results: One year after sinus surgery, the prevalence of intermittently colonised patients had decreased by 38%, while the prevalence of non-colonised patients had increased by 150%. The frequency of pulmonary samples with CF pathogens was reduced after surgery. Specific IgG against P. aeruginosa decreased after six months. Additionally, the self reported symptoms of chronic rhinosinusitis and quality of life improved. Conclusion: Combined sinus surgery and postoperative systemic and topical antibiotic treatment significantly reduced the frequency of pulmonary samples positive for CF pathogens in the first year after sinus surgery.