Open AccessSteroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-beta1
Author(s) -
S. Aversa,
C. Ondolo,
G. Abbadessa,
F. Piccione,
V. Carriero,
A. Fulcheri,
A. Lauria,
S. De Francia,
S. Racca
Publication year - 2012
Publication title -
rhinology (amsterdam. online)/rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.275
H-Index - 57
eISSN - 1996-8604
pISSN - 0300-0729
DOI - 10.4193/rhino11.249
Subject(s) - glucocorticoid receptor , glucocorticoid , medicine , receptor , transforming growth factor beta , endocrinology , alpha (finance) , radioligand , microbiology and biotechnology , biology , construct validity , nursing , patient satisfaction
Glucocorticoids (GCs) are considered drugs of choice for treating nasal polyps (NPs). However, a subset of patients shows a limited clinical response even to high doses of GCs. Altered expression of glucocorticoid receptors (GRs), namely GR-alpha; and GR-beta;, is a potential mechanism underlying GC insensitivity. GCs modulate the expression of several cytokines, including transforming growth factor-beta (TGF-beta), which may contribute to cellular proliferation in NPs. The study investigates some biomolecular features of GC-resistant NPs, and examines possible differences from normal mucosa (NM).