Steroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-beta1 | Zendy

S. Aversa | Zendy; C. Ondolo | Zendy; G. Abbadessa | Zendy; F. Piccione | Zendy; V. Carriero | Zendy; A. Fulcheri | Zendy; A. Lauria | Zendy; S. De Francia | Zendy; S. Racca | Zendy

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Steroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-beta1

Author(s) -

S. Aversa,

C. Ondolo,

G. Abbadessa,

F. Piccione,

V. Carriero,

A. Fulcheri,

A. Lauria,

S. De Francia,

S. Racca

Publication year - 2012

Publication title -

rhinology journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.275

H-Index - 57

eISSN - 1996-8604

pISSN - 0300-0729

DOI - 10.4193/rhino11.249

Subject(s) - glucocorticoid receptor , glucocorticoid , medicine , receptor , transforming growth factor beta , endocrinology , alpha (finance) , radioligand , microbiology and biotechnology , biology , construct validity , nursing , patient satisfaction

Glucocorticoids (GCs) are considered drugs of choice for treating nasal polyps (NPs). However, a subset of patients shows a limited clinical response even to high doses of GCs. Altered expression of glucocorticoid receptors (GRs), namely GR-alpha; and GR-beta;, is a potential mechanism underlying GC insensitivity. GCs modulate the expression of several cytokines, including transforming growth factor-beta (TGF-beta), which may contribute to cellular proliferation in NPs. The study investigates some biomolecular features of GC-resistant NPs, and examines possible differences from normal mucosa (NM).

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