Open AccessAntimicrobial peptides in nasal secretion and mucosa with respect to Staphylococcus aureus colonization in chronic rhinosinusitis with nasal polyps
Author(s) -
M.L. Thienhaus,
J. Wohlers,
R. Podschun,
J. Hedderich,
P. Ambrosch,
M. Laudien
Publication year - 2011
Publication title -
rhinology (amsterdam. online)/rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.275
H-Index - 57
eISSN - 1996-8604
pISSN - 0300-0729
DOI - 10.4193/rhino11.072
Subject(s) - staphylococcus aureus , nasal polyps , mucous membrane of nose , medicine , antimicrobial peptides , microbiology and biotechnology , antimicrobial , immunology , immunohistochemistry , stimulation , beta defensin , staphylococcal infections , pathology , bacteria , biology , genetics
Nasal carriage of Staphylococcus aureus in patients with chronic rhinosinusitis with nasal polyps (NP) is hypothesized to have pathophysiological impact on the disease. Antimicrobial peptides (AMP), especially human beta-defensin-3 (hBD-3) and LL-37, are an important part of the multifactorial defence against microorganisms in barrier organs like the nasal mucosa. The interaction of S. aureus colonization and AMP in nasal secretions and mucosa of NP were investigated in this study.