Open AccessPredictive significance of Charcot-Leyden Crystal mRNA levels in nasal brushing for nasal polyp recurrence
Author(s) -
Sihan Qi,
Bing Yan,
C Liu,
C Wang,
Luo Zhang
Publication year - 2019
Publication title -
rhinology (amsterdam. online)/rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.275
H-Index - 57
eISSN - 1996-8604
pISSN - 0300-0729
DOI - 10.4193/rhin19.296
Subject(s) - medicine , nasal polyps , chronic rhinosinusitis , endoscopic sinus surgery , gastroenterology , biomarker , logistic regression , endoscopy , clinical significance , surgery , pathology , biochemistry , chemistry
Tissue eosinophils have been shown to be associated with polyp recurrence in chronic rhinosinusitis with nasal polyps (CRSwNP). We addressed whether the mRNA levels of Charcot-Leyden Crystal (CLC) in nasal brushing samples, a molecule mainly released from activated eosinophils, could serve as an effective non-invasive biomarker to predict polyp recurrence.