Fipronil upregulates inflammatory cytokines and MUC5AC expression in human nasal epithelial cells | Zendy

Soyoung Kwak | Zendy; YouYoun Choi | Zendy; H.G. Na | Zendy; Chang Hoon Bae | Zendy; Suk-Jong Song | Zendy; Y.-D. Kim | Zendy

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Fipronil upregulates inflammatory cytokines and MUC5AC expression in human nasal epithelial cells

Author(s) -

Soyoung Kwak,

YouYoun Choi,

H.G. Na,

Chang Hoon Bae,

Suk-Jong Song,

Y.-D. Kim

Publication year - 2019

Publication title -

rhinology journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.275

H-Index - 57

eISSN - 1996-8604

pISSN - 0300-0729

DOI - 10.4193/rhin19.172

Subject(s) - fipronil , mapk/erk pathway , p38 mitogen activated protein kinases , cytokine , medicine , proinflammatory cytokine , signal transduction , kinase , inflammation , mucin , immunology , microbiology and biotechnology , biology , pathology , agronomy , pesticide

Airway inflammation and excessive mucin production are pathophysiological characteristics of airway diseases. Fipronil, a pesticide, is being extensively used in agriculture and veterinary medicine worldwide. However, this compound impairs immune function in non-target organisms. The present study aimed to evaluate the effect of fipronil on pro-inflammatory cytokine and mucus production and signalling pathways in human primary nasal METHODOLOGY: The effect of fipronil on pro-inflammatory cytokine and MUC5AC expression and the signalling pathway of fipronil were investigated using real-time PCR, enzyme immunoassays, immunofluorescence, and immunoblot analysis with specific inhibitors and small interfering RNA.

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