Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records | Zendy

Elizabeth M. Williamson | Zendy; Spiros Denaxas | Zendy; Stephen Morris | Zendy; Caroline S. Clarke | Zendy; Mike Thomas | Zendy; Hannah Evans | Zendy; Kenan Direk | Zendy; Arturo González-Izquierdo | Zendy; Paul Little | Zendy; Valerie Lund | Zendy; Helen Blackshaw | Zendy; Anne GM Schilder | Zendy; Carl Philpott | Zendy; C. Hopkins | Zendy; James R. Carpenter | Zendy

Open Access

Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records

Author(s) -

Elizabeth M. Williamson,

Spiros Denaxas,

Stephen Morris,

Caroline S. Clarke,

Mike Thomas,

Hannah Evans,

Kenan Direk,

Arturo González-Izquierdo,

Paul Little,

Valerie Lund,

Helen Blackshaw,

Anne GM Schilder,

Carl Philpott,

C. Hopkins,

James R. Carpenter

Publication year - 2019

Publication title -

rhinology journal

Language(s) - English

Resource type - Journals

eISSN - 1996-8604

pISSN - 0300-0729

DOI - 10.4193/rhin18.237

Subject(s) - medicine , medical prescription , chronic rhinosinusitis , primary care , cohort , health records , cohort study , medical record , electronic health record , emergency medicine , intensive care medicine , health care , family medicine , pharmacology , economics , economic growth

Macrolide antibiotics have demonstrated important anti-inflammatory and immunomodulatory properties in chronic rhinosinusitis (CRS) patients. However, reports of increased risks of cardiovascular events have led to safety concerns. We investigated the risk of all-cause and cardiac death, and cardiovascular outcomes, associated with macrolide use.

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