Open AccessNovel roles for nasal epithelium in the pathogenesis of chronic rhinosinusitis with nasal polyps
Author(s) -
Marjolein Cornet,
Katriina Kostamo,
Albert B. Rinia,
Aeilko H. Zwinderman,
Danielle van Egmond,
E. J. J. de Groot,
Wytske Fokkens,
Cornelis M. van Drunen
Publication year - 2019
Publication title -
rhinology (amsterdam. online)/rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.275
H-Index - 57
eISSN - 1996-8604
pISSN - 0300-0729
DOI - 10.4193/rhin18.128
Subject(s) - nasal polyps , pathogenesis , medicine , immunology , neutrophilia , epithelium , pathology , respiratory epithelium
Airway epithelial cells have a well-accepted role in the regulation of local inflammatory processes in allergic and innate defence responses. However, their role the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) is unclear. The objective was to investigate whether potential differences in the mRNA expression profile of nasal epithelia from healthy individuals and from CRSwNP patients would shed new light on disease mechanisms.