TSLP regulates eotaxin-1 production by nasal epithelial cells from patients with eosinophilic CRSwNP | Zendy

Wei Wei Wang | Zendy; Dongyan LU | Zendy; Ming Zheng | Zendy; J.G. Zhang | Zendy; B. Zhang | Zendy

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TSLP regulates eotaxin-1 production by nasal epithelial cells from patients with eosinophilic CRSwNP

Author(s) -

Wei Wei Wang,

Dongyan LU,

Ming Zheng,

J.G. Zhang,

B. Zhang

Publication year - 2018

Publication title -

rhinology journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.275

H-Index - 57

eISSN - 1996-8604

pISSN - 0300-0729

DOI - 10.4193/rhin17.045

Subject(s) - thymic stromal lymphopoietin , eotaxin , medicine , immunology , inflammation , eosinophilic esophagitis , eosinophil , allergic inflammation , stat3 , eosinophilic , chemokine , signal transduction , pathology , asthma , biology , microbiology and biotechnology , disease

Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by Th2-skewed inflammation with eosinophilic infiltration. Thymic stromal lymphopoietin (TSLP) promotes the development of allergic inflammation. Although increased TSLP is found in eCRSwNP, little is known about whether TSLP regulates eotaxin-1 production, a potent eosinophil chemoattractant that recruits and activates eosinophils.

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