Open AccessTSLP regulates eotaxin-1 production by nasal epithelial cells from patients with eosinophilic CRSwNP
Author(s) -
W W Wang,
Dongyan LU,
Ming Zheng,
J G Zhang,
B Zhang
Publication year - 2018
Publication title -
rhinology (amsterdam. online)/rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.275
H-Index - 57
eISSN - 1996-8604
pISSN - 0300-0729
DOI - 10.4193/rhin17.045
Subject(s) - thymic stromal lymphopoietin , eotaxin , medicine , immunology , inflammation , eosinophilic esophagitis , eosinophil , allergic inflammation , stat3 , eosinophilic , chemokine , signal transduction , pathology , asthma , biology , microbiology and biotechnology , disease
Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by Th2-skewed inflammation with eosinophilic infiltration. Thymic stromal lymphopoietin (TSLP) promotes the development of allergic inflammation. Although increased TSLP is found in eCRSwNP, little is known about whether TSLP regulates eotaxin-1 production, a potent eosinophil chemoattractant that recruits and activates eosinophils.