Bacterial immune evasion via an IL-10 mediated host response, a novel pathophysiologic mechanism for chronic rhinosinusitis | Zendy

J.S. Schwartz | Zendy; S. Al-Mot | Zendy; M.F. Endam | Zendy; Saud Alromaih | Zendy; Joaquı́n Madrenas | Zendy; Martin Desrosiers | Zendy

Open Access

Bacterial immune evasion via an IL-10 mediated host response, a novel pathophysiologic mechanism for chronic rhinosinusitis

Author(s) -

J.S. Schwartz,

S. Al-Mot,

M.F. Endam,

Saud Alromaih,

Joaquı́n Madrenas,

Martin Desrosiers

Publication year - 2017

Publication title -

rhinology journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.275

H-Index - 57

eISSN - 1996-8604

pISSN - 0300-0729

DOI - 10.4193/rhin16.199

Subject(s) - intraepithelial lymphocyte , medicine , immune system , immunohistochemistry , immunology , staphylococcus aureus , cd8 , foxp3 , microarray , pathology , biology , gene expression , gene , biochemistry , bacteria , genetics

Staphylococcus aureus is a frequently implicated pathogen in chronic rhinosinusitis (CRS). S. aureus may promote commensalism by downregulating pro-inflammatory T cell host responses via an IL-10 mediated pathway. This finding, coupled with the observation that S. aureus and CD8+ T cell numbers are inversely correlated in CRS mucosa, suggests that S. aureus may evade immune destruction via IL-10 induction. To support this hypothesis, we evaluated i) whether IL-10 levels differ in CRS compared to controls (CTL) using microarray and immunohistochemistry and ii) whether IL-10 levels correlate with S. aureus and CD8+ T cell levels.

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