Open AccessBacterial immune evasion via an IL-10 mediated host response, a novel pathophysiologic mechanism for chronic rhinosinusitis
Author(s) -
Schwartz Js,
Sawsan Al-Mot,
Endam Mf,
Saud Alromaih,
Joaquı́n Madrenas,
Marie-Pierre Desrosiers
Publication year - 2017
Publication title -
rhinology (amsterdam. online)/rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.275
H-Index - 57
eISSN - 1996-8604
pISSN - 0300-0729
DOI - 10.4193/rhin16.199
Subject(s) - intraepithelial lymphocyte , medicine , immune system , immunohistochemistry , immunology , staphylococcus aureus , cd8 , foxp3 , microarray , pathology , biology , gene expression , gene , biochemistry , bacteria , genetics
Staphylococcus aureus is a frequently implicated pathogen in chronic rhinosinusitis (CRS). S. aureus may promote commensalism by downregulating pro-inflammatory T cell host responses via an IL-10 mediated pathway. This finding, coupled with the observation that S. aureus and CD8+ T cell numbers are inversely correlated in CRS mucosa, suggests that S. aureus may evade immune destruction via IL-10 induction. To support this hypothesis, we evaluated i) whether IL-10 levels differ in CRS compared to controls (CTL) using microarray and immunohistochemistry and ii) whether IL-10 levels correlate with S. aureus and CD8+ T cell levels.