Effect of Oral Contraceptives on Bone Mineral Density | Zendy

Christos Ampatzis | Zendy; Stefanos Zervoudis | Zendy; Georgios Iatrakis | Zendy; Georgios Mastorakos | Zendy

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Effect of Oral Contraceptives on Bone Mineral Density

Author(s) -

Christos Ampatzis,

Stefanos Zervoudis,

Georgios Iatrakis,

Georgios Mastorakos

Publication year - 2022

Publication title -

acta endocrinologica (bucharest)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.249

H-Index - 13

eISSN - 1843-066X

pISSN - 1841-0987

DOI - 10.4183/aeb.2022.355

Subject(s) - medicine , discontinuation , medroxyprogesterone acetate , bone mineral , progestin , levonorgestrel , combined oral contraceptives , medroxyprogesterone , desogestrel , pill , estrogen , gynecology , osteoporosis , population , family planning , endocrinology , physiology , research methodology , pharmacology , environmental health

Contraceptives are widely used in our times and a lot of research has been conducted to clarify their impact on Bone Mineral Density. Combined Oral Contraceptives (COCs) may be detrimental to the BMD of adolescents. However, low-dose are more protective than ultra-low-dose COCs. When it comes to premenopause and perimenopause, COCs have no impact on BMD in women with good ovarian function and no estrogen deficiency. In women with impaired ovarian function, it seems that COCs have a positive influence on BMD. Progestin only-pills may not affect BMD, but further research is needed. Depot medroxyprogesterone acetate injection (DMPA) has a negative impact, especially in adolescents, which is duration related but evidence shows that BMD recovers after discontinuation. Levonorgestrel-releasing intrauterine system (LNG-IUS) has no impact on BMD.

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