LncRNA HOTTIP Promotes Ovarian Cancer Cell Invasion And Metastasis By Stabilizing Hif-1α In The Anoxic Cellular Microenvironment | Zendy

S Zhang | Zendy; Qing Ma | Zendy; Xiaoying Wu | Zendy; Ping Chen | Zendy

Open Access

LncRNA HOTTIP Promotes Ovarian Cancer Cell Invasion And Metastasis By Stabilizing Hif-1α In The Anoxic Cellular Microenvironment

Author(s) -

S Zhang,

Qing Ma,

Xiaoying Wu,

Ping Chen

Publication year - 2022

Publication title -

acta endocrinologica (bucharest)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.249

H-Index - 13

eISSN - 1843-066X

pISSN - 1841-0987

DOI - 10.4183/aeb.2022.263

Subject(s) - gene knockdown , apoptosis , cell cycle , viability assay , flow cytometry , cell , cancer research , cell growth , long non coding rna , metastasis , ovarian cancer , biology , microbiology and biotechnology , chemistry , cancer , rna , gene , biochemistry , genetics

The high recurrence rate and low survival rate of ovarian cancer (OC) patients are closely related to an anoxic environment. We aim to study the mechanism of long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) on hypoxia ovarian cancer cells (OCC) and its mechanism was investigated.

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