Changes of WNT/B-Catenin Signaling and Differentiation Potential of Bone Marrow Mesenchymal Stem Cells in Process of Bone Loss in Ovariectomized Rats | Zendy

Wenxia Ren | Zendy; D Gan | Zendy; Gamze Tan | Zendy; Hang Xue | Zendy; N Li | Zendy; Zixin Xu | Zendy

Open Access

Changes of WNT/B-Catenin Signaling and Differentiation Potential of Bone Marrow Mesenchymal Stem Cells in Process of Bone Loss in Ovariectomized Rats

Author(s) -

Wenxia Ren,

D Gan,

Gamze Tan,

Hang Xue,

N Li,

Zixin Xu

Publication year - 2020

Publication title -

acta endocrinologica (bucharest)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.249

H-Index - 13

eISSN - 1843-066X

pISSN - 1841-0987

DOI - 10.4183/aeb.2020.156

Subject(s) - adipogenesis , ovariectomized rat , wnt signaling pathway , chemistry , mesenchymal stem cell , oil red o , endocrinology , medicine , bone marrow , osteoporosis , catenin , microbiology and biotechnology , signal transduction , biology , biochemistry , estrogen

In vitro studies of the changes about osteoblastogenesis and adipogenesis potential of BMSCs were not clear. As it is the critical pathway for osteogenic differentiation and bone formation, whether or not Wnt/β-catenin signalling is involved in the changes of osteogenic and adipogenic potential of BMSCs and participates in bone content decrease of ovariectomized (OVX)osteoporosis rats has been rarely reported.

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