Open AccessHuman Bioavailability and Pharmacokinetic Profile of Different Formulations Delivering Alpha Lipoic Acid
Author(s) -
Fiorenzo Mignini,
Cinzia Carla Nasuti,
G Gioventù,
Valerio Napolioni,
Piera Di Martino
Publication year - 2012
Publication title -
journal of clinical and cellular immunology
Language(s) - English
Resource type - Journals
ISSN - 2155-9899
DOI - 10.4172/scientificreports.418
Subject(s) - bioavailability , alpha lipoic acid , pharmacokinetics , pharmacology , alpha (finance) , lipoic acid , medicine , chemistry , biochemistry , antioxidant , surgery , oxidative stress , construct validity , patient satisfaction
Alpha-lipoic acid (ALA) is an important micronutrient with several pharmacologic as well as antioxidant properties.\udOral formulations present problems due to characteristics of the molecule and of the pharmaceutical forms. It is\udknown that ALA is poorly soluble; therefore to increase the solubility was reticulated in an amphiphilic matrix like\udlecithin. The goal of the present study was to characterize the bioavailability of new formulation and to compare the\udhuman pharmacokinetics profiles of two different pharmaceutical form: tablets and soft gel capsules following single\udoral administration of a ALA 600 mg. Blood samples were collected up to 8 h post dosing, and plasma á-lipoic acid\udconcentrations were determined by Liquid Chromatography Mass Spectrometry (LC/MS/MS) detection. The results\udrevealed that after rapid dissolution there is a good solubilisation by lecithin and that the two formulations show the\udsame human pharmacokinetic profile. Tablet formulation is more versatile than soft capsules because it makes it\udpossible to administer 600 mg of ALA with good compliance. The properties of the new formulation ensure rapid\udrelease in vivo and good bioavailability with high ALA content per unit dose and excellent homogeneity of release