Open AccessIn vitro Analysis of the Hemostatic Properties of Whole Blood Products Prepared with a Platelet-Sparing Leukoreduction Filter
Author(s) -
; Zielinski,
Stubbs,
Polites Sf,
Anke Xue,
Haugen Dal,
Richard L. Emery,
Jenkins Dh,
MiSuk Park
Publication year - 2018
Publication title -
journal of thrombosis and circulation: open access
Language(s) - English
Resource type - Journals
ISSN - 2572-9462
DOI - 10.4172/2572-9462.1000124
Subject(s) - leukoreduction , thromboelastography , platelet , whole blood , thromboelastometry , filtration (mathematics) , coagulation , chemistry , medicine , chromatography , surgery , mathematics , statistics
Warm fresh whole blood (WFWB) is an ideal resuscitation fluid for exsanguinating patients but there are myriad logistic and infectious issues associated with its use. Cold whole blood (CWB) may be an acceptable alternative to the reconstituted whole blood (RWB), the current standard of care. A leukoreduction filter has been developed which maintains platelet count while eliminating white blood cells but its effect on platelet function is unknown. We hypothesize that CWB will retain an acceptable functional coagulation profile after filtration and over time.