Open AccessSickle Cell Disease Clinical Trials and Phenotypes
Author(s) -
Chinedu Ezekekwu,
Taiwo R. Kotila,
Titilola S. Akingbola,
Guillaume Lettre,
Victor R. Gordeuk,
Richard S. Cooper,
Michael R. DeBaun,
Baba Inusa,
Bamidele O. Tayo
Publication year - 2018
Publication title -
journal of tropical diseases
Language(s) - English
Resource type - Journals
ISSN - 2329-891X
DOI - 10.4172/2329-891x.1000259
Subject(s) - haplotype , disease , clinical trial , phenotype , gene , medicine , biology , genetics , bioinformatics , pathology , genotype
Sickle cell disease, one of the world’s most common genetic disorders is prevalent in sub-Saharan Africa. The trans-Atlantic slave trade accounted for the gene movement from Africa to the Caribbean and United States of America and lately, migration has resulted in the introduction of the gene to the United Kingdom and other parts of Europe. Different haplotypes exist, however the differences in these haplotypes are not sufficient to explain the different clinical variations within the same region or different settings.