Open AccessDirect Measurement of Lipase Inhibition by Orlistat Using a Dissolution Linked In Vitro Assay
Author(s) -
Daniel R. Lewis,
Dongzhou J. Liu
Publication year - 2012
Publication title -
clinical pharmacology and biopharmaceutics
Language(s) - English
Resource type - Journals
ISSN - 2167-065X
DOI - 10.4172/2167-065x.1000103
Subject(s) - orlistat , lipase , dissolution , chromatography , chemistry , dissolution testing , hydrolysis , enzyme kinetics , in vitro , substrate (aquarium) , enzyme , biochemistry , medicine , biology , organic chemistry , ecology , biopharmaceutics classification system , weight loss , active site , obesity
To develop a bio-assay that would be able to directly test gastrointestinal and/or dissolution samples to determine lipase activity and inhibition by Orlistat.