Open AccessMRI Assessment of Associations between Brown Adipose Tissue and Cachexia in Murine Pancreatic Ductal Adenocarcinoma
Author(s) -
Yaqi Zhang,
Su Hu,
Junjie Shangguan,
Liang Pan,
Xin Zhou,
Vahid Yaghmai,
Yury Velichko,
Chunhong Hu,
Jia Yang,
Zhuoli Zhang
Publication year - 2019
Publication title -
internal medicine open access
Language(s) - English
Resource type - Journals
ISSN - 2165-8048
DOI - 10.4172/2165-8048.1000301
Subject(s) - pancreatic cancer , magnetic resonance imaging , adipose tissue , cachexia , medicine , brown adipose tissue , cancer , pathology , biomarker , malignancy , biology , radiology , biochemistry
As the major thermogenic tissue in body, the brown adipose tissue (BAT) was recently identified as an important factor to induce the rapid weight loss and malnutrition in malignancy. Current methods for detecting and quantifying brown adipose tissue (BAT) are in limited use. The aim of this study was to evaluate the changes of BAT tissue and its function in the development of pancreatic ductal adenocarcinoma (PDAC) by using magnetic resonance imaging (MRI).