Open AccessRodent Models and Behavioral Outcomes of Cervical Spinal Cord Injury
Author(s) -
Sydney A. Geissler,
Christine E. Schmidt,
Timothy Schallert
Publication year - 2013
Publication title -
journal of spine
Language(s) - English
Resource type - Journals
ISSN - 2165-7939
DOI - 10.4172/2165-7939.s4-001
Subject(s) - spinal cord injury , medicine , spinal cord , histopathology , rodent model , rat model , physical medicine and rehabilitation , neuroscience , pathology , psychology , psychiatry
Rodent spinal cord injury (SCI) models have been developed to examine functional and physiological deficits after spinal cord injury with the hope that these models will elucidate information about human SCI. Models are needed to examine possible treatments and to understand histopathology after SCI; however, they should be considered carefully and chosen based on the goals of the study being performed. Contusion, compression, transection, and other models exist and have the potential to reveal important information about SCI that may be related to human SCI and the outcomes of treatment and timing of intervention.