Determinants of Skeletal Muscle Hypertrophy and the Attenuated Hypertrophic Response at Old Age

In 2012 we will again see the impressive achievements of many athletes during the London Olympic Games. In\udparticular for weightlifters success is dependent on the power- and force-generating capacity of their muscles, which\udin turn are strongly determined by muscle mass. Many athletes and bodybuilders therefore train intensively to develop\udas much muscle hypertrophy as possible. Unlimited hypertrophy, however, is impossible. Limitations may be imposed\udby the peak forces that the tendons, bones and joints can cope with, but also by factors within the muscles themselves.\udFor instance, an increase in pennation angle, which accompanies hypertrophy, beyond 450 would result in a reduction\udin muscle strength even if muscle mass continuous to increase. There also is a trade-off between metabolism and\uddiffusion, where highly oxidative fibers require shorter diffusion distances, and hence smaller fibers, for adequate\udoxygen supply to the mitochondria, than glycolytic fibers. A similar situation applies to the myonuclei where transcripts\udare distributed over the cell mainly by diffusion and unbridled hypertrophy would, at least in theory, cause serious\udproblems with fiber maintenance. Despite these limiting factors muscles in bodybuilders can be as much as 74%\udlarger than in the normal population. Elderly people have a lower muscle mass that may cause problems with daily life\udactivities and an increase in muscle strength would improve their quality of life. There are indications, however, that\udthe maximal attainable hypertrophy is significantly reduced in the elderly. Here it is suggested that while individual\udfibers in the elderly may hypertrophy to a similar extent as their younger counterparts, the age-related loss of muscle\udfibers is an additional limiting factor of the whole muscle hypertrophy at old age