Open AccessStatic and Dynamic Cognitive Reserve Proxy Measures: Interactions with Alzheimer’s Disease Neuropathology and Cognition
Author(s) -
Michael Malek-Ahmadi,
Sophie Lu,
YanYan Chan,
Sylvia E. Perez,
Kewei Chen,
Elliott J. Mufson
Publication year - 2017
Publication title -
journal of alzheimer's disease and parkinsonism
Language(s) - English
Resource type - Journals
ISSN - 2161-0460
DOI - 10.4172/2161-0460.1000390
Subject(s) - neuropathology , cognitive reserve , episodic memory , cognition , proxy (statistics) , psychology , alzheimer's disease , audiology , disease , clinical psychology , medicine , cognitive impairment , psychiatry , machine learning , computer science
Years of education are the most common proxy for measuring cognitive reserve (CR) when assessing the relationship between Alzheimer's disease (AD) neuropathology and cognition. However, years of education may be limited as a CR proxy given that it represents a specific timeframe in early life and is static. Studies suggest that measures of intellectual function provide a dynamic estimate of CR that is superior to years of education since it captures the effect of continued learning over time. The present study determined whether dynamic measures of CR were better predictors of episodic memory and executive function in the presence of AD pathology than a static measure of CR.