Open AccessNeurotoxin-Induced Catecholaminergic Loss in the Colonic Myenteric Plexus of Rhesus Monkeys
Author(s) -
Jeanette Shultz,
Henry Resnikoff,
Viktorya Bondarenko,
Valerie Joers,
Andrés Mejía,
Heather A. Simmons,
Marina E. Emborg
Publication year - 2016
Publication title -
journal of alzheimer's disease and parkinsonism
Language(s) - English
Resource type - Journals
ISSN - 2161-0460
DOI - 10.4172/2161-0460.1000279
Subject(s) - myenteric plexus , enteric nervous system , catecholaminergic , neurotoxin , neurochemical , tyrosine hydroxylase , medicine , pathology , neurodegeneration , dysautonomia , endocrinology , parkinson's disease , constipation , dopamine , gastroenterology , immunohistochemistry , disease
Constipation is a common non-motor symptom of Parkinson's disease (PD). Although pathology of the enteric nervous system (ENS) has been associated with constipation in PD, the contribution of catecholaminergic neurodegeneration to this symptom is currently debated. The goal of this study was to assess the effects of the neurotoxin 6-hydroxydopamine (6-OHDA) on the colonic myenteric plexus and shed light on the role of catecholaminergic innervation in gastrointestinal (GI) function.