Open AccessA Role for Sox2 in the Adult Cerebellum
Author(s) -
Nikolaos Mandalos,
Ioannis Karampelas,
Marannia Saridaki,
Ronald D.G. McKay,
Mark L. Cohen,
Eumorphia Remboutsika
Publication year - 2018
Publication title -
journal of stem cell research and therapy
Language(s) - English
Resource type - Journals
ISSN - 2157-7633
DOI - 10.4172/2157-7633.1000433
Subject(s) - cerebellum , neuroscience , sox2 , biology , psychology , cognitive science , computer science , genetics , gene , transcription factor
The cerebellum, a derivative of the hindbrain, plays a crucial role in balance and posture as well as in higher cognitive and locomotive processes. Cerebellar development is initiated during the segmental phase of hindbrain formation. Here, we describe the phenotype, of a single surviving adult conditional mouse mutant mouse, in which Sox2 function is ablated in embryonic radial glial cells by means of hGFAP-CRE. The single Sox2 RGINV/mosaic adult mutant mouse displays motor disability, microsomia, reduced Central Nervous System (CNS) size and cerebellar defects associated with human genetically related congenital abnormalities.