Open AccessLost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells
Author(s) -
R. Padmanabhan,
Kevin G. Chen,
Michael M. Gottesman
Publication year - 2014
Publication title -
journal of stem cell research and therapy
Language(s) - English
Resource type - Journals
ISSN - 2157-7633
DOI - 10.4172/2157-7633.1000180
Subject(s) - abcg2 , embryonic stem cell , translation (biology) , messenger rna , biology , stem cell , microbiology and biotechnology , atp binding cassette transporter , transporter , computational biology , gene , genetics
The expression and function of the ATP-binding cassette (ABC) transporter ABCG2 have been studied for two decades in both adult and cancer stem cells. However, this important ABC transporter has not been well characterized in human embryonic stem cells (hESCs). Studies designed to understand the role of ABCG2 in hESCs are still in their initial stages. Several recent reports on expression patterns of the ABCG2 gene in hESCs contain contradictory results at both the mRNA and protein levels. In this review, we provide possible explanations for these discrepancies in ABCG2 expression patterns. We discuss micro-RNA-mediated regulatory roles in controlling ABCG2 mRNA stability and translation, which are associated with hESC pluripotency and differentiation.