Open AccessCell Models for the Study of Sex Steroid Hormone Neurobiology
Author(s) -
Chang Su,
Nataliya Rybalchenko,
Derek A. Schreihofer,
Meharvan Singh,
Babak Abbassi,
Rebecca L. Cunningham
Publication year - 2012
Publication title -
journal of steroids and hormonal science.
Language(s) - English
Resource type - Journals
ISSN - 2157-7536
DOI - 10.4172/2157-7536.s2-003
Subject(s) - neuroscience , forebrain , steroid hormone , hormone , estrogen receptor , androgen receptor , biology , receptor , estrogen , steroid hormone receptor , sex hormone receptor , sex steroid , steroid , endocrinology , central nervous system , genetics , prostate cancer , cancer , breast cancer
To date many aspects of neurons and glia biology remain elusive, due in part to the cellular and molecular complexity of the brain. In recent decades, cell models from different brain areas have been established and proven invaluable toward understanding this complexity. In the field of steroid hormone neurobiology, an important question is: what is the profile of steroid hormone receptor expression in these specific cell lines? Currently, a clear summary of such receptor profiling is lacking. For this reason, we summarized in this review the expression of estrogen, progesterone, and androgen receptors in several widely used cell lines (glial and neuronal) derived from the forebrain and midbrain, based on our own data and that from the literature. Such information will aid in the selection of specific cell lines used to test hypotheses related to the biology of estrogens, progestins, and/or androgens.